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M94A2379.TXT
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1994-10-25
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Document 2379
DOCN M94A2379
TI Activated CD8+ lymphocytes in HIV infection.
DT 9412
AU De Martinis M; D'Ostilio A; Ginaldi L; Profeta FV; Quaglino D; Clinica
Medica University of L'Aquila, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):318 (abstract no. PC0203). Unique
Identifier : AIDSLINE ICA10/94370196
AB There are evidence that HIV disease progression is associated with
elevated numbers of CD8+ cells that bear the phenotypic surface markers
of activated cells (AIDS 1992; 6:793, Clin. Exp. Immunol. 1992; 90:376).
This activation of the Immune System may play a role in maintaining an
adequate response to lessen the progression of infection. 94
seropositive drug addicts were stratified into four groups based on
clinical data: 10 Asymptomatic, 26 LAS, 33 ARC and 25 AIDS. Lymphocyte
subsets and the expression of HLA-DR on CD8+ cells from peripheral blood
samples were examined by dual-color flow-cytometry using standardized
lysed blood method. As control groups were enrolled 22 seronegative drug
addicts and 22 healthy subjects. CD8+HLA-DR+ lymphocytes were
significantly increased in the HIV-1+ group respect to control groups:
mean values HIV + 6.38 + 4.6, HIV-drug addicts 1.13 + 1.7 and healthy
1.0 + 0.7 p < 0.001). The proportion of CD8+HLA-DR+ cells increased
progressively with each more advanced HIV clinical stage (from 6% in
Asymptomatics to 8.6% in AIDS). There is a significant inverse
correlation between CD8+HLA-DR and CD4+ cell counts in the Asymptomatic,
LAS and ARC group, while the correlation between the levels of
lymphocyte subsets seem to become direct in AIDS patients. Activated
CD8+ cells may represent a specific immune response to the virus,
contributing to the maintenance of asymptomatic state as long as
possible. The progressive damage of the Immune System can explain why
CD8+HLA-DR+ cells decrease at the end of the natural history of the
disease, when infection overcome.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY Antigens, CD8/*ANALYSIS
AIDS-Related Complex/IMMUNOLOGY Flow Cytometry Human HIV
Infections/*IMMUNOLOGY *HIV-1 HLA-DR Antigens/ANALYSIS Leukocyte
Count *T-Lymphocyte Subsets MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).